American Cruise Lines

Upper Mississippi (St. Paul to St. Louis)

Upper Mississippi (St. Paul to St. Louis), 8-night on American Serenade by American Cruise Lines. Departs July 17, 2026 from Saint Paul, Minnesota to Saint Louis, Missouri. Itinerary includes Saint Paul, Minnesota, La Crosse, Wisconsin,...

Cruise summary

Cruise line
American Cruise Lines
Ship
American Serenade
Departure
July 17, 2026
Duration
8-night
Embarkation
Saint Paul, Minnesota
Disembarkation
Saint Louis, Missouri

Itinerary highlights

  1. Saint Paul, Minnesota
  2. La Crosse, Wisconsin
  3. Dubuque, Iowa
  4. Davenport, Iowa
  5. Hannibal, Missouri
  6. Alton, Illinois